This is a guide for Paragon, as most are out of date or lacking.
So this guide has all the information on how to use Paragon all in one place.
Though warning mistakes could be present.

Best Spec:
61 Paragon, 10 Warlord, 5 Tempest
Burninalways Rift Quick Paragon Guide 1

Alternative Spec:
61 Paragon, 10 Warlord, 5 Champion (F2P)
Burninalways Rift Quick Paragon Guide 2

Buffs:
Turn the Blade
Way of the Wind
Way of the River
Enhanced Conductivity
Recovery Posture
Focus of Body

Standard Rotation:
Rising Waterfall, Final Blessing or Open the Stream are Follow Up attacks and will award 2 Attack Points.
Follow Up attacks can only be used once an Attack Point awarding ability is used.
Using Combat Focus will allow Follow Up attacks to be used as the next ability.

You should be using a Attack Point awarding ability then a Follow Up attack to build 3 Attack Points.
Then consuming those 3 Attack Points with either Shifting Blades or Reaping Harvest.

Keep Open the Stream active on the target refreshing when it expires.
While keeping Setting Moon active on yourself.

Though you shouldn’t refresh Open the Stream while Alacrity is active.
Also when Shifting Blades is active don’t use Open the Stream, until all stacks are consumed.

Keep Tranquility, Death Touch, Shifting Blades Combat Focus on cooldown

When Shifting Blades is active use Tranquility to consume one of the stacks.
Use Combat Focus right after Shifting Blades then use Reaping Harvest.

While Alacrity is active using Rising Waterfall, Final Blessing or Reaping Harvest will consume 2 stacks of Shifting Blades.

Keep Alacrity on cooldown, time with raid cooldowns if possible.

For disconnects use Grasping the Horizon and continue with your normal rotation.
If Grasping the Horizon is on cooldown use Furry instead.

For aoe toggle on Sweeping Blades.
Though you should only be using Sweeping Blades when facing 4 enemies and just continue with your normal rotation. Less than 4 it’s better to not use Sweeping Blades and to dps each one at a time.

Starting Blocks:
Without Raid Cooldown:
Grasping the Horizon > Setting Moon > Open the Stream > Shifting Blades > Combat Focus
Alacrity > Reaping Harvest > Tranquility > Rising Waterfall > Reaping Harvest
Setting Moon > Rising Waterfall > Reaping Harvest
Death Touch > Rising Waterfall > Reaping Harvest

With Raid Cooldown:
Grasping the Horizon > Setting Moon > Open the Stream > Reaping Harvest
Death Touch > Rising Waterfall > Shifting Blades > Combat Focus
Alacrity > Reaping Harvest > Tranquility > Rising Waterfall > Reaping Harvest
Setting Moon > Rising Waterfall > Reaping Harvest
Setting Moon > Rising Waterfall > Reaping Harvest

Noob Macro:

It basically combines the Tranquility and Death Touch macros below into one for a simpler rotation.

#show Setting Moon
suppressmacrofailures
cast [notactive] Turn the Blade
cast Final Blessing
cast Rising Waterfall
cast Death Touch
cast Tranquility
cast Setting Moon
cast Shock Pulse
cast @self Power Manipulation

Macros:
#show Tranquility
suppressmacrofailures
cast [notactive] Turn the Blade
cast Tranquility
cast Final Blessing
cast Rising Waterfall
cast Setting Moon
cast Shock Pulse
cast @self Power Manipulation

#show Death Touch
suppressmacrofailures
cast [notactive] Turn the Blade
cast Death Touch
cast Final Blessing
cast Rising Waterfall
cast Setting Moon
cast Shock Pulse
cast @self Power Manipulation

#show Open the Stream
suppressmacrofailures
cast Open the Stream
cast Setting Moon

#show Reaping Harvest
suppressmacrofailures
cast Reaping Harvest
cast Skyfall

Karuulalert:

Code:
KA::AK4vreNqtk9Fu2yAUhl8lT5CBAWOLK2zDtoutUpvdRbKIzRxUB0eYbmq3vfswS6M2sbakmrA
lm3N0zv+dH2722i78Vi/uvNNqxyBbsX2vHrVbeuU67eOODO/NSSaXoioFTggXFeIYJwyEXBkWCOv
WfPWsUl69W3/5uFYb0xv/WJtmsOO6GXYb5evmod8Zq7wZ7LJtR5YSyDKAWQqmBy4TEuqxUnxeidv
pC8aFQNCyet6Of2nomTD5871T497YLqr8MDjzNNgXQEeS2TwuK0ILynMCEl4Anl+Ms1VuE6ppV4c
+Vrna6WlCvn6KWBQSRlH+NiwQsMo4roUcmodxDudVPLgCBUgyWXCCqyr0vgKj1Va39ehVfx/8j+J
pdu7Jj5DR3I+/5iHkLMTdd63jzItetXqW4zSFy5LnecYhTZMsIwJdjNIFDmea+nkXQHIwYzpjZ2b
wxptv+owm+QuN9n5S+mk4PWHyD8rLOMcElYLkKSkTjGlRXcxhTbf1BzsCxMGR/JygVKO/Rj/vVeN
CnzkbjrFwIyjIMKQcIkg4hRfr3iunusHWKpZqpoCK4jOM3n7F4+C3oe0/jtFJCkeCp5hWMkOICJx
fjzEeKtabWPHoBMT/5W78BrhErSE

Additional Guide Tips Welcomed!